Neurobiology of Language Laboratory (NLL)

In the NNL Laboratory different instruments can be integrated (synchronized) to explore the neurophysiological activity of the brain during speech perception and production processing. Also, saccades and fixations of eye movements can be monitored during diversified audio-visual and reading tasks.

Repetitive Transcranial Magnetic Stimulation (rTMS) is a powerful neuroscientific tool with the potential to non invasively identify brain-behavior relationships in humans. It can modulate brain activity by either increasing (excitatory) or decreasing (inhibitory) neural firing. Thus, rMTS allows researchers to understand if the brain areas are selectively involved in specific cognitive processing.

An event-related potential (ERP) is a measured brain response, that is the direct, time-locked, electrical result of a specific sensory, cognitive, or motor event. Recorded via electroencephalography (EEG), ERPs isolate small voltage fluctuations buried inside ongoing brain activity by averaging multiple trials together.

The actiCAP slim 64-channel active electrode system is a go-to solution for reliable and flexible high-quality EEG recordings. It combines active electrodes based on high-quality Ag/AgCl sensors with a new type of integrated noise subtraction circuits delivering even lower noise levels than any other “normal” active electrodes achieves.

General features: higher impedance recordings,  per-electrode LED impedance feedback,  wide hardware compatibility easy electrode replacement.

Specific feature:

  • Thin: The actiCAP slim is a fully active EEG electrode with impedance conversion circuitry and multi-color LED impedance feedback scaled down by a factor of three compared to the first version.
  • Lightweight: Less total weight and a low center of gravity reduce motion artifacts. The low weight per electrode makes a high-density cap significantly lighter and hence more comfortable to wear.
  • Robust: The Ag/AgCl pellets are covered by the electrode housing from the sides. This protects the pellet from accidental damages.
    Easy preparation: The larger opening in the actiCAP slim makes the electrode preparation very easy. It even allows the usage of paste for long-term recordings like in sleep research!
    Low profile (6 mm): ideal for EEG-TMS applications. This allows positioning of the stimulator coil very closely to the head, resulting in minimal loss of TMS pulse power. Combining actiCAP slim with our high sampling rate actiCHamp amplifier, will give you the benefit of ultra-short artifacts.

BESA Research is the most widely used software for source analysis and dipole localization in EEG, MEG, Evoked Potentials and ERP research. BESA Research has been developed on the basis of over 20 years experience in human brain research by Michael Scherg, University of Heidelberg, and Patrick Berg, University of Konstanz.
BESA Research provides many advanced features for automatic source localization, fast modeling and easy, interactive hypothesis testing. Source analysis can be performed simultaneously on multiple conditions with advanced constraints based on anatomy and physiology. In addition to discrete multiple dipole modeling, all major distributed imaging methods are also available for comparison. This makes BESA a complete all-in-one tool for source imaging.
BESA has all the features required to perform offline processing of continuously acquired EEG and MEG data using external and internal triggers, e.g. generated from an EMG channel or by spatio-temporal pattern search. Triggers are automatically mapped into predefined paradigms to provide for fast selection of combinations of averages (addition, subtraction, subsets). Based on the spatial components approach of Berg and Scherg (1994), artifacts (e.g. eye and ECG) can be corrected on the fly from EEG, MEG, and ERP data.
Special viewing options allow for easy selection of averaged or single epochs of interest (e.g. spikes) and for immediate source localization and analysis. Digitized 3D sensor locations can be used to coregister EEG or MEG data with structural and functional MRI. Fitted dipole sources can be superimposed directly to the individual MR image.

It allows the researcher to place the coil of the magnetic stimulator on the cerebral cortex of the speaker, with or without magnetic resonance. It offers a 3D reconstruction and the stereotaxic navigation in human brain.

It allows the researcher to monitor the movements of the head, of the hands as well as to monitor tools suited to biomechanics analysis, to stereotaxic localization, to telerobotics and to virtual reality applications.

It enables the researcher to create personalized auditory and visual stimuli.

E-Prime is on of the most comprehensive stimulus presentation software available. 

An infrared-rays system suited to studying eye and saccadic movements. It is equipped with remote optics and monitoring system of framing and inclination (working at 120, 240, e 360Hz). It allows the informant to move his head freely in 30 square centimeters and it does not need to dispose of a support to block the informant head.